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Vitamins B12 and folate are essential for cognitive and cardiovascular health, energy metabolism, normal growth and development, as well as early fetal development. Genetic differences can impair the metabolism and conversion of standard B12 and folic acid, however, leading to poor absorption and use by the body.

Natural Factors BioCoenzymatedÔ Methylfolate plus Methylcobalamin (Folate + B12) is a one-a-day, non-GMO, sublingual tablet that features active folate from 6S-5-MTHF (Quatrefolic®)[BN1]  and vitamin B12 in their coenzymated forms for direct nutritional support, even for those with genetic differences that impair nutrient metabolism – no conversion required!

Research suggests that Quatrefoliccan increase blood folate levels up to three times more effectively than folic acid!


Dissolve 1 tablet daily under the tongue or as directed by a health care practitioner. Keep out of the reach of children.

Medicinal Ingredients

Each tablet contains:  
Folate (from (6S)-5-methyltetrahydrofolic acid (MTHF), glucosamine salt, Quatrefolic®) 1000 mcg
Vitamin B12 (methylcobalamin) 50 mcg

Non-Medicinal Ingredients

Lactose, microcrystalline cellulose, croscarmellose sodium,*Farm Fresh FactorsTM, vegetable grade magnesium stearate (lubricant).

*Active Vegetables – organic kale, organic alfalfa, organic cilantro leaf, organic parsley, caperberry, sprouted garlic, organic artichoke,organic black radish, organic dandelion, barleygrass, pepper, organic celery seed,organic beetroot, organic tomato; Cruciferous Vegetables – A broad spectrum of fully active glucosinolates and myrosinase enzymes from wasabi rhizome (Wasabia japonica) and fresh freeze-dried sprouted broccoli, organic upland cress, daikon, red radish, organic cauliflower,organic cabbage, organic arugula, organic watercress leaf; Ultra Fruit Polyphenols – grape, pomegranate, strawberry, organic blueberry, raspberry, bilberry, organic Indian gooseberry, schizandra berry, red orange, organic acai berry; Herbals and Plants – Theracurmin® curcumin, organic decaffeinated green tea extract, organic ginger rhizome,organic echinacea, organic oregano, organic peppermint,organic spearmint; Whole Plant Sea Vegetables – organic spirulina, organic chlorella, red algae, blue green algae, kelp.


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