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SAMe (pronounced "sammy") is short for S-adenosyl-L-methionine or S-adenosyl-methionine, a natural molecule formed in the body by methionine and adenosyl-triphosphate (ATP). Supplemental SAMe helps to raise serotonin, dopamine, and phosphatidylserine levels.

SAMe works actively with folic acid and vitamin B12, and together can promote healthy brain functioning. Natural Factors SAMe is specially coated for ease of swallowing and maximum bioavailability, which also enhances SAMe's stability. 

Individuals who are using prescription antidepressants or who suffer from bipolar disorder should use this product only under the supervision of a health care practitioner

  • Helps to raise serotonin, dopamine and phosphatidylserine levels.
  • Without the side effects of prescription antidepressants.
  • Support for arthritic disorders.
  • Helps to promote bile flow and inactivate excess estrogens.


SAMe should always be taken on an empty stomach. For mood balance: 1-4 tablets 2 times daily or as directed by a health care practitioner. For osteoarthritic pain: 1-3 tablets 2 times daily or as directed by a health care practitioner.

Medicinal Ingredients:

Each tablet contains:  
S-Adenosyl-L-Methionine (SAMe) 200 mg
(from 400 mg of S-Adenosyl-L-Methionine Disulfate Tosylate)  

Non-Medicinal Ingredients:

Microcrystalline Cellulose, Mannitol, Enteric Coating (Methacrylic Acid Copolymer, Talc, Triethyl Citrate, Glyceryl Palmitostearate, Silica, Titanium Dioxide, Medium Chain Triglycerides, Yellow Iron Oxide), Glyceryl Behenate, Vegetable Grade Magnesium Stearate (Lubricant), Silica, Sodium Starch Glycolate.